Surfactant Protein C antibody (AA 60-180)

Catalog No. ABIN1098147

This anti-Surfactant Protein C antibody is a Mouse Monoclonal antibody detecting Surfactant Protein C in ELISA. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for Surfactant Protein C antibody (AA 60-180) (ABIN1098147)

Target: Surfactant Protein C (SFTPC)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Surfactant Protein C antibody is un-conjugated

Application: ELISA

Clone: 5E6A9

Product Details anti-Surfactant Protein C Antibody

Binding Specificity: AA 60-180

Purpose: SFTPC Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SFTPC (AA: 60-180 ) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Surfactant Protein C antibody (ABIN1098147)

Zhong, Zhou, Ann, Minoo, Liu, Banfalvi, Krishnaveni, Dubourd, Demaio, Willis, Kim, duBois, Crandall, Beers, Borok: "Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein." in: American journal of respiratory cell and molecular biology, Vol. 45, Issue 3, pp. 498-509, (2011) (PubMed).

Wang, Bridges, Na, Xu, Weaver: "Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33377-83, (2009) (PubMed).

Target Details for Surfactant Protein C

Target: Surfactant Protein C (SFTPC)

Alternative Name: SFTPC

Background: This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90 % lipids and 10 % proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Molecular Weight: 21 kDa

UniProt: P11686