BIN1 antibody (AA 189-398)

Catalog No. ABIN1105531

This Mouse Monoclonal antibody specifically detects BIN1 in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Human, Mouse, Rat, Pig and Chicken.

Quick Overview for BIN1 antibody (AA 189-398) (ABIN1105531)

Target: BIN1 (Bridging Integrator 1 (BIN1))

Reactivity: Human, Mouse, Rat, Pig, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This BIN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: BN-1

Product Details anti-BIN1 Antibody

Binding Specificity: AA 189-398

Specificity: Recognizes BIN1. No cross reactivity with other proteins.

Purification: Affinity Chromatography

Immunogen: Recombinant polypeptide containing amino acids 189-398 of Human Bin1.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1.2 % Sodium Acetate or neutral PBS.

Concentration: 0.1 mg/mL

Buffer: 1.2 % Sodium Acetate containing 2 mg BSA and 0.01 mg Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BIN1

Target: BIN1 (Bridging Integrator 1 (BIN1))

Alternative Name: BIN1 / AMPHL

Background: BIN1 (AMPH2) is a novel human gene product with features of a tumor suppressor protein. BIN1 gene to chromosome 2q14. Loss of BIN1 expression appears to be a frequent aberration in human hepatocellular carcinomas . mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the functional interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei.Synonyms: Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, Myc box-dependent-interacting protein 1

Gene ID: 274, 9606

UniProt: O00499