BPI antibody

Catalog No. ABIN1105556

The Mouse Monoclonal anti-BPI antibody is suitable to detect BPI in samples from Human. It has been validated for EIA.

Quick Overview for BPI antibody (ABIN1105556)

Target: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BPI antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 3F9

Product Details anti-BPI Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for BPI

Target: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Alternative Name: BPI

Background: The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.Synonyms: Bactericidal permeability-increasing protein, CAP57

Gene ID: 9606

UniProt: P17213