CHAF1B antibody

Catalog No. ABIN1105633

This Mouse Monoclonal antibody specifically detects CHAF1B in WB, IF and IP. It exhibits reactivity toward Human.

Quick Overview for CHAF1B antibody (ABIN1105633)

Target: CHAF1B (Chromatin Assembly Factor 1, Subunit B (p60) (CHAF1B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHAF1B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: P60-24

Product Details anti-CHAF1B Antibody

Specificity: This antibody reacts with 60 kDa membrane protein CAF-1 on Immunoprecipitation and Immunocytochemistry.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein-A Sepharose Chromatography of hybridoma supernatant.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Preservative: Without preservative

Target Details for CHAF1B

Target: CHAF1B (Chromatin Assembly Factor 1, Subunit B (p60) (CHAF1B))

Alternative Name: CAF-1 Subunit B

Background: Chromatin assembly factor-1 (CAF-1) is a highly conserved member of the histone chaperone family that promotes chromatin assembly during DNA replication in eukaryotes. CAF-1 acts as a specialized assembly factor to target newly synthesized histones to replicating DNA. CAF-1 consists of a complex of three subunits of 150 kDa (p150), 60 kDa (p60), and 48 kDa (p48). The histone chaperone Asf1 (anti-silencing function 1) protein can interact directly with the p60 subunit of CAF-1, possibly linking CAF-1 activity to DNA repair. CAF-1 may also play a regulatory role in DNA damage processing and checkpoint control.Synonyms: CAF1A, CAF1P60, CHAF1B, Chromatin assembly factor 1 subunit B, Chromatin assembly factor I p60 subunit, M-phase phosphoprotein 7, MPHOSPH7, MPP7

Gene ID: 8208