COL2 antibody

Catalog No. ABIN1106744

The Mouse Monoclonal anti-COL2 antibody has been validated for IHC (p), IHC (fro), Func and EIA. It is suitable to detect COL2 in samples from Human, Mouse, Rat, Chicken and Cow.

Quick Overview for COL2 antibody (ABIN1106744)

Target: COL2 (Collagen, Type II (COL2))

Reactivity: Human, Mouse, Rat, Chicken, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This COL2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: M2139

Product Details anti-COL2 Antibody

Specificity: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1 (cat.no. AM26375PU-N), binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat, bovine, chicken

Purification: Protein G

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for COL2

Target: COL2 (Collagen, Type II (COL2))

Alternative Name: Collagen Type II

Background: Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II

Gene ID: 1280

NCBI Accession: NP_001835

UniProt: P02458