JAM3 antibody

Catalog No. ABIN1107891

The Rat Monoclonal anti-JAM3 antibody (Clone 19H36) (ABIN1107891) specifically detects JAM3 in IP, IHC (fro) and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for JAM3 antibody (ABIN1107891)

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This JAM3 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: 19H36

Product Details anti-JAM3 Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Protein G

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for JAM3

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Alternative Name: JAM3 / JAM-C

Background: Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney.Synonyms: Junctional adhesion molecule 3, Junctional adhesion molecule C

Gene ID: 83964

NCBI Accession: NP_075766

UniProt: Q9D8B7