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LY96 antibody

This Mouse Monoclonal antibody specifically detects LY96 in Func. It exhibits reactivity toward Human.
Catalog No. ABIN1108189

Quick Overview for LY96 antibody (ABIN1108189)

Target

See all LY96 Antibodies
LY96 (Lymphocyte Antigen 96 (LY96))

Reactivity

  • 48
  • 14
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 41
  • 13
Mouse

Clonality

  • 44
  • 10
Monoclonal

Conjugate

  • 31
  • 10
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This LY96 antibody is un-conjugated

Application

  • 41
  • 16
  • 14
  • 10
  • 7
  • 6
  • 6
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Functional Studies (Func)

Clone

18H10
  • Cross-Reactivity (Details)

    Species reactivity (tested):Human

    Purification

    Protein G

    Immunogen

    TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein

    Isotype

    IgG2b
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Concentration

    0.1 mg/mL

    Buffer

    PBS, 0.1 % bovine serum albumin

    Storage

    4 °C

    Storage Comment

    Store at 2 - 8 °C.
  • Target

    LY96 (Lymphocyte Antigen 96 (LY96))

    Alternative Name

    MD-2

    Background

    TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells.Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2

    UniProt

    Q9Y6Y9

    Pathways

    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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