The Mouse Monoclonal anti-NEFL antibody (Clone 1H3) (ABIN1108416) specifically detects NEFL in WB, IF, FACS, IHC (p) and EIA.
The antibody is reactive with Human samples.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS, 0.05 % sodium azide, 0,5 % BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Target
NEFL
(Neurofilament, Light Polypeptide (NEFL))
Alternative Name
Neurofilament L (68kDa)
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.Synonyms: 68 kDa neurofilament protein, NEFL, NF-L, NF68, Neurofilament L