PNPLA6 antibody (C-Term)

Catalog No. ABIN1108496

The Rabbit Polyclonal anti-PNPLA6 antibody is suitable to detect PNPLA6 in samples from Zebrafish (Danio rerio). It has been validated for WB, IHC (p) and IHC (fro).

Quick Overview for PNPLA6 antibody (C-Term) (ABIN1108496)

Target: PNPLA6 (Patatin-Like phospholipase Domain Containing 6 (PNPLA6))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNPLA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PNPLA6 Antibody

Binding Specificity: AA 1323-1348, C-Term

Specificity: This antibody detects NTE at aa 1323-1348. No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (tested):Zebrafish

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of fish PNPLA6 (1323-1348 amino acid)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for PNPLA6

Target: PNPLA6 (Patatin-Like phospholipase Domain Containing 6 (PNPLA6))

Alternative Name: NTE

Background: Patatin-like phospholipase domain containing 6 (PNPLA6), also known as Neuropathy target esterase (NTE), is a human gene. Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. The genetic or chemical reduction of Nte activity results in a neurological phenotype of hyperactivity in mammals and indicate that EOPF toxicity occurs directly through inhibition of Nte without the requirement for Nte gain of function or aging.Synonyms: Neuropathy target esterase, PNPLA6

Gene ID: 10908

NCBI Accession: NP_006693

UniProt: Q8IY17

Pathways: Ribonucleoside Biosynthetic Process