PROS1 antibody

Catalog No. ABIN1108756

This Rat Monoclonal antibody specifically detects PROS1 in WB. It exhibits reactivity toward Human.

Quick Overview for PROS1 antibody (ABIN1108756)

Target: PROS1 (PROS) (Protein S (PROS))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This PROS1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: PS7

Product Details anti-PROS1 Antibody

Specificity: Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. Allows specific detection of cells carrying PS by flow cytometry.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity C Chromatography on Protein G

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for PROS1

Target: PROS1 (PROS) (Protein S (PROS))

Background: In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.Synonyms: PROS, Vitamin K-dependent protein S

Gene ID: 5627

NCBI Accession: NP_000304

UniProt: P07225