S100A12 antibody

Catalog No. ABIN1108920

This anti-S100A12 antibody is a Mouse Monoclonal antibody detecting S100A12 in WB, EIA and IHC (fro). Suitable for Human.

Quick Overview for S100A12 antibody (ABIN1108920)

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This S100A12 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 19F5

Product Details anti-S100A12 Antibody

Specificity: Reacts with 10 kDa Human S100A12 protein. No cross reaction with the other S100 protein family.

Purification: Affinity Chromatography on Protein A

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: PBS, None

Target Details for S100A12

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Alternative Name: S100A12

Background: S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains. They are characterised by their cell-type specific expression patterns. S100A12 is a member of the calgranulin sub-family. Calgranulins are S100 proteins that are expressed by neutrophils and also found in infiltrating monocytes and granulocytes during chronic inflammation. S100A12 is expressed in neutrophils and monocytes. It is highly abundant in resting neutrophils, comprising 5 % of total cytostolic protein. S100A12 is a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.Synonyms: CAAF1, CAGC, CGRP, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, EN-RAGE, Extracellular newly identified RAGE-binding protein, Neutrophil S100 protein, S100 calcium-binding protein A12, S100-A12

Gene ID: 6283

Pathways: Toll-Like Receptors Cascades, S100 Proteins