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SMAD2 antibody (N-Term)

This Rabbit Polyclonal antibody specifically detects SMAD2 in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN1109059

Quick Overview for SMAD2 antibody (N-Term) (ABIN1109059)

Target

See all SMAD2 Antibodies
SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reactivity

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Human, Mouse, Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This SMAD2 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

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    N-Term

    Specificity

    This antibody detects SMAD2 (+SMAD3) (N-term). No cross reactivity with other proteins.

    Cross-Reactivity (Details)

    Species reactivity (tested):Human, mouse, rat

    Purification

    Immunogen affinity purified

    Immunogen

    Synthetic peptide corresponding to the N-terminal of human SMAD2/3 .Remarks: Sequence is identical to identical to the related mouse and rat sequence.

    Isotype

    IgG
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Reconstitution

    1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target

    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

    Alternative Name

    SMAD2

    Background

    SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Transforming growth factor (TGF)-beta stimulation leads to phosphorylation and activation of Smad2 and Smad3, which form complexes with Smad4 that accumulate in the nucleus and regulate transcription of target genes. Smad2 and Smad3 share highly homology. SMAD2/SMAD3 signal transduction appeared to be important in the regulation of muscle-specific genes. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development.Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development.Synonyms: JV18-1, MAD homolog 2, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, SMAD 2, SMAD family member 2, SMAD-2

    Gene ID

    4087

    NCBI Accession

    NP_001003652

    UniProt

    Q15796

    Pathways

    Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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