Spectrin beta Chain, Erythrocyte (SPTB) antibody

Catalog No. ABIN1109122

This Mouse Monoclonal antibody specifically detects in WB, IF and IP. It exhibits reactivity toward Human.

Quick Overview for Spectrin beta Chain, Erythrocyte (SPTB) antibody (ABIN1109122)

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: DB2

Product Details

Specificity: The antibody clone AF10 is specific to the 240 kDa Erythroid alpha-Spectrin. This antibody is suitable for Various immunochemical reactions to detect Erythroid Spectrins, Identification of Erythroid leukemias (Ref.1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogen: Ghost proteins of Human red blood cells. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 1.0 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Alternative Name: Spectrin beta Chain (Erythrocyte) / SPTB

Background: Erythroid spectrins, some other proteins of erythroid cytoskeleton, and the transmembrane protein band 3 are highly specific for erythrocytes and their progenitors. They are more reliable markers for erythroid differentiation than Glycophorin A, the commonly used marker for erythroid differentiation, because Glycophorin A is expressed also in many cell lines otherwise exhibiting mainly megakaryotic charasteristics.Synonyms: Beta-I spectrin, SPTB1

Gene ID: 6710

NCBI Accession: NP_000338

UniProt: P11277

Pathways: Regulation of Actin Filament Polymerization