Synaptophysin antibody

Catalog No. ABIN1109181

The Mouse Monoclonal anti-Synaptophysin antibody (Clone 171B5) (ABIN1109181) specifically detects Synaptophysin in WB and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for Synaptophysin antibody (ABIN1109181)

Target: Synaptophysin (SYP)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 171B5

Product Details anti-Synaptophysin Antibody

Specificity: Reacts with human and mouse Synaptophysin.

Purification: Protein A agarose

Immunogen: Purified synaptic vesicle fraction from guinea pig cerebrum

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservtives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: Synaptophysin / SYP

Background: Synaptophysin (also referred to as SVP38 and p38) is an acidic Ca2+ binding glycoprotein of about 38 kDa which exist largely in synaptic vesicles. It has 4 transmembrane regions and is reported to be a major cholesterol-binding protein in synaptic vesicles. Synaptophysin may regulate synaptic exocytosis by competing with proteins such as SNAP25 and syntaxins to bind to synaptobrevin (vesicle-associated membrane protein, or VAMP). It may also participate in synaptic endocytosis, which contributes to rapid recycling of synaptic vesicle.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker

Gene ID: 6855

NCBI Accession: NP_003170

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity