Transglutaminase 2 antibody

Catalog No. ABIN1109303

The Mouse Monoclonal anti-Transglutaminase 2 antibody has been validated for WB, IHC (fro) and EIA. It is suitable to detect Transglutaminase 2 in samples from Human and Guinea Pig. There is 1 publication available.

Quick Overview for Transglutaminase 2 antibody (ABIN1109303)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivity: Human, Guinea Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transglutaminase 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: 7D2

Product Details anti-Transglutaminase 2 Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, Guinea Pig.

Purification: Affinity Chromatography on Protein A

Isotype: IgG3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

References for anti-Transglutaminase 2 antibody (ABIN1109303)

Maffei, Laverrière, Wu, Triboulet, Perrinet, Duchateau, Matondo, Hollis, Gourley, Rupp, Keillor, Subtil: "Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells." in: The EMBO journal, Vol. 39, Issue 8, pp. e102166, (2020) (PubMed).

Target Details for Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: Transglutaminase-2

Background: Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling