TTR antibody

Catalog No. ABIN1112826

This anti-TTR antibody is a Mouse Monoclonal antibody detecting TTR in WB. Suitable for Human.

Quick Overview for TTR antibody (ABIN1112826)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: F28

Product Details anti-TTR Antibody

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the region of human PA.

Isotype: IgG2b

Application Details

Application Notes: WB (1:5000). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Prealbumin, PA

Background: Prealbumin (PA), as known as Transthyretin (TTR), is an evolutionarily conserved serum and cerebrospinal fluid (CSF) protein that transports holo-retinol-binding protein (RBP) and thyroxine (T4). It is a 62-kDa homotetramer with a dimer of dimers quaternary structure that is synthesized mainly in liver, choroid plexus, retinal pigment epithelium for secretion into the bloodstream, cerebrospinal fluid and the eye, respectively. It maintains normal levels of retinol, retinol-binding protein, and thyroid hormone in the circulating plasma. TTR misfolding and aggregation is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC).

Pathways: Hormone Transport