TTR antibody (C-Term)

Catalog No. ABIN652227

The Rabbit Polyclonal anti-TTR antibody (Clone RB19657) (ABIN652227) specifically detects TTR in WB, FACS, IF and IHC (p). The antibody is reactive with Human and Rat samples.

Quick Overview for TTR antibody (C-Term) (ABIN652227)

Target: TTR (Transthyretin (TTR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB19657

Product Details anti-TTR Antibody

Binding Specificity: AA 71-98, C-Term

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TTR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids from the C-terminal region of human TTR.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:2000. IHC-P: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: TTR

Background: Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Molecular Weight: 15887

Gene ID: 7276

NCBI Accession: NP_000362

UniProt: P02766

Pathways: Hormone Transport