TdT antibody

Catalog No. ABIN1112828

The Mouse Monoclonal anti-TdT antibody has been validated for WB. It is suitable to detect TdT in samples from Human.

Quick Overview for TdT antibody (ABIN1112828)

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TdT antibody is un-conjugated

Application: Western Blotting (WB)

Clone: N153

Product Details anti-TdT Antibody

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of human TDT.

Isotype: IgG2b

Application Details

Application Notes: WB (1:1000). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 25% Glycerol and 0.05% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TdT

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Alternative Name: Terminal deoxynucleotidyl transferase, TDT

Background: Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. 1 TDT cDNA contains an open reading frame of 1530 base pairs (bp) corresponding to a protein containing 510 amino acids. 2 TDT is a useful marker in the diagnosis of acute lymphoblastic leukemia (ALL) (French-American-British [FAB] L1 and L2) and is most useful in distinguishing ALL from mature B-lymphoid neoplasms, such as Burkitt lymphoma (FAB L3) and other lymphoid malignancies. 3

Pathways: DNA Damage Repair