MCAM antibody
Quick Overview for MCAM antibody (ABIN1112867)
Target
See all MCAM AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Purification
- affinity purified
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Isotype
- IgG
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Application Notes
- WB (1:1000-2000), ICC (1:100-500), Flow Cyt (1:10-100). Other applications have not been tested. The optimal dilutions should be determined by end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
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Preservative
- Sodium azide, Thimerosal (Merthiolate)
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.
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Expiry Date
- 12 months
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- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
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Alternative Name
- CD146
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Background
- CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene. 1 CD146 belongs to the immunoglobulin superfamily and expressed in all types of human endothelial cells. The regulated expression of CD146 at areas of cell-cell junction and strongly suggest involvement of CD146 as a mediator of cell-cell interaction. 2 CD146 has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, 3 and its expression may be linked to multipotency, mesenchymal stem cells with greater differentiation potential express higher levels of CD146 on the cell surface. 4
Target
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