LRPAP1 antibody

Catalog No. ABIN112189

This Mouse Monoclonal antibody specifically detects LRPAP1 in WB, IF and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for LRPAP1 antibody (ABIN112189)

Target: LRPAP1 (Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRPAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 7F1

Product Details anti-LRPAP1 Antibody

Specificity: This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor). It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.

Purification: Affinity Chromatography on Protein A .

Immunogen: Human RAP.

Isotype: IgG1

Application Details

Application Notes: Immunoblotting. Immunofluorescence. Immunohistochemistry: 1/20. Ligand-binding assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in 1 mL distilled water.

Buffer: PBS buffer, pH 7.4 containing 0.5 % BSA as stabilizer.

Handling Advice: This product is photosensitive and should be protected from light

Storage: 4 °C

Storage Comment: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Target Details for LRPAP1

Target: LRPAP1 (Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 (LRPAP1))

Alternative Name: LRPAP1 / A2MRAP

Background: Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B, binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.Synonyms: Alpha-2-MRAP, Alpha-2-macroglobulin receptor-associated protein, Low density lipoprotein receptor-related protein-associated protein 1, RAP

Gene ID: 4043

NCBI Accession: NP_002328

UniProt: P30533