Periostin antibody (full length) (Biotin)

Catalog No. ABIN1169102

The Mouse Monoclonal anti-Periostin antibody has been validated for WB, IHC and ELISA. It is suitable to detect Periostin in samples from Human and Mouse. There is 1 publication available.

Quick Overview for Periostin antibody (full length) (Biotin) (ABIN1169102)

Target: Periostin (POSTN)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Periostin antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: Stiny-1

Product Details anti-Periostin Antibody (Biotin)

Binding Specificity: full length

Specificity: Recognizes human and mouse periostin.

Cross-Reactivity: Human, Mouse (Murine)

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Purity: >95 % (SDS-PAGE)

Immunogen: Full-length human periostin.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-Periostin antibody (Biotin) (ABIN1169102)

Arikkatt, Ullah, Short, Zhang, Gan, Loh, Werder, Simpson, Sly, Mazzone, Spann, Ferreira, Upham, Sukkar, Phipps: "RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma." in: eLife, Vol. 6, (2018) (PubMed).

Target Details for Periostin

Target: Periostin (POSTN)

Alternative Name: Periostin

Background: Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

UniProt: Q15063