CD7 antibody (Biotin)

Catalog No. ABIN118543

This Mouse Monoclonal antibody specifically detects CD7 in FACS and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CD7 antibody (Biotin) (ABIN118543)

Target: CD7

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD7 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: LT7

Product Details anti-CD7 Antibody (Biotin)

Specificity: This antibody is a single chain cell surface glycoprotein of 40 kDa, expressed by T cells, NK cells and thymocytes. CD7 is also expressed by tumour cells in some cases of acute myeloid leukaemia.

Purification: Affinity chromatography on Protein A

Immunogen: Normal human peripheral blood lymphocytes. Spleen cells from immunised BALB/c mice were fused with cells of the X63.653 mouse myeloma cell line.

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % Bovine Serum Albumin as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CD7

Target: CD7

Alternative Name: CD7

Background: CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin superfamily. CD7 is expressed by the majority of thymocytes and mature T cells, NK cells and pre-B cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. The function of CD7 is not yet known although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux and CD7 expression is induced by ionomycin. The CD7 Molecule has been reported to be the receptor for the IgM-Fc portion (FcR mu) on the surface of T cells.Synonyms: GP40, Leu-9, T-cell leukemia antigen, TP41

Gene ID: 924

NCBI Accession: NP_006128

UniProt: P09564

Pathways: Cell-Cell Junction Organization