CD59 antibody

Catalog No. ABIN120694

This Mouse Monoclonal antibody specifically detects CD59 in FACS and Func. It exhibits reactivity toward Human and Pig.

Quick Overview for CD59 antibody (ABIN120694)

Target: CD59

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD59 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: MEM-129

Product Details anti-CD59 Antibody

Specificity: The antibody MEM-129 reacts with CD59 (Protectin).

Purification: Thiophilic Adsorption-Affinity Chromatography and Size-Exclusion Chromatography.

Purity: > 95 % (by SDS-PAGE).

Immunogen: Human peripheral blood lymphocytes

Isotype: IgM

Application Details

Application Notes: Flow Cytometry. Functional Studies (The antibody activates T-cells).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), preserved by filter sterilization, approx. pH 7.4

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 4-8 °C. DO NOT FREEZE! Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background: CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

Gene ID: 966

UniProt: P13987

Pathways: Complement System