PPM1A antibody

Catalog No. ABIN121149

This anti-PPM1A antibody is a Mouse Monoclonal antibody detecting PPM1A in WB, IP, IHC (p) and EIA. Suitable for Human and Mouse.

Quick Overview for PPM1A antibody (ABIN121149)

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPM1A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: P6c7

Product Details anti-PPM1A Antibody

Specificity: This antibody detects Protein Phosphatase 2C alpha (PP2C alpha).

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human PP2C alpha protein

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot: Recommended dilution range: 1:250 approx. 1:1000. Recommended starting dilution: 1:250. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2-8 °C for one month or at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for PPM1A

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Alternative Name: Protein Phosphatase 1A / PPM1A

Background: Protein phosphatase 2C(PP2Cα) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNK MAPK pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2C, the prototypical member of the PPM family.Synonyms: PP2C-alpha, PPPM1A, Protein phosphatase 2C isoform alpha, Protein phosphatase IA

UniProt: P35813