Growth Hormone 1 antibody

Catalog No. ABIN121163

The Mouse Monoclonal anti-Growth Hormone 1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect Growth Hormone 1 in samples from Human.

Quick Overview for Growth Hormone 1 antibody (ABIN121163)

Target: Growth Hormone 1 (GH1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Growth Hormone 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: G3H5

Product Details anti-Growth Hormone 1 Antibody

Specificity: The antibody recognizes human Growth Hormone (hGH). Other species not tested.

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human Growth Hormone protein

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot (1:500 - 1:1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for Growth Hormone 1

Target: Growth Hormone 1 (GH1)

Alternative Name: Somatotropin / Growth Hormone / GH1

Background: Human growth hormone(hGH, somatotropin), a protein hormone from the anterior lobe of the pituitary gland, comprises a single polypeptide chain of 191 amino acid residues. The 20KDa variant form of human growth hormone (20KDa hGH) presents in extracts from pituitary glands and it differs from the major form of hGH (22KDa, 191 amino acid) by the deletion of amino acid residues 32-46. The growth hormone amino acid sequence varies considerably between species, and non-primate growth hormones have little activity in man. Main functions of hGH and 20KDa hGH are the stimulation of somatic and bone growth, as well as an increase in the size and mass of organs and tissues. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.Synonyms: Growth hormone 1, HGH, Pituitary growth hormone

Gene ID: 2688

UniProt: P01241

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process