TACR1 antibody (C-Term)

Catalog No. ABIN122523

This anti-TACR1 antibody is a Rabbit Polyclonal antibody detecting TACR1 in IHC (p). Suitable for Human, Rat, Mouse, Dog, Guinea Pig, Cow, Horse, Rabbit and Hamster.

Quick Overview for TACR1 antibody (C-Term) (ABIN122523)

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Cow, Horse, Rabbit, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TACR1 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Tachykinin receptor 1 (TACR1) at C-term. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DTNB (44 %).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Immunoaffinity chromatography.

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 1-40 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TACR1

Target: TACR1 (Tachykinin Receptor 1 (TACR1))

Background: Tachykinin receptor 1, a member of the tachykinin receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.Synonyms: NK-1 receptor, NK-1R, NK1R, SPR, Substance-P receptor, TAC1R

Gene ID: 6869

UniProt: P25103

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration