Ankyrin G antibody

Catalog No. ABIN1304539

This Mouse Monoclonal antibody specifically detects Ankyrin G in IHC, ICC and IEM. It exhibits reactivity toward Human.

Quick Overview for Ankyrin G antibody (ABIN1304539)

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ankyrin G antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM)

Clone: N106-65

Product Details anti-Ankyrin G Antibody

Specificity: No off-targets reported for Ankyrin-B

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-Ankyrin-G (Staining) mouse monoclonal primary antibody is produced in-house from hybridoma clone N106/65. It detects human, mouse, and rat Ankyrin-G (Staining), and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Ankyrin-G (Staining) mouse monoclonal primary antibody from hybridoma clone N106/65. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Purity: > 90% specific antibody

Immunogen: Fusion protein ~1000 amino acids of Ankyrin-G (accession number E9PE32) produced recombinantly in E. Coli

Isotype: IgG2b

Application Details

Application Notes:

Dilution Range: IHC: 1:500

Dilution Range: ICC: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 24 months

Target Details for Ankyrin G

Target: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Alternative Name: Ankyrin-G

Background:

Synonyms: Ankyrin-3 (ANK-3) (Ankyrin-G)

Target Description: Ankyrin-G (ankyrin 3) is a member of the Ankyrin family which consists of Ankyrin R (1), Ankyrin B (2) and Ankyrin G (3) all of which are expressed in the nervous system. Ankyrins are structural proteins that aid in the attachment of integral membrane proteins with the spectrin-actin cytoskeleton, and thus targets voltage-gated sodium channels, potassium channels, cell adhesion molecules and others at the nodes of Ranvier and axonal initial segments (AIS). Variants in Ankyrin G have been linked to bipolar disorder.

Gene Name Alternatives: ANK3

Molecular Weight: < 200 kDa

UniProt: E9PE32

Pathways: Synaptic Membrane, Maintenance of Protein Location, Skeletal Muscle Fiber Development