KCNT1 antibody (AA 1168-1237)

Catalog No. ABIN1304962

This Mouse Monoclonal antibody specifically detects KCNT1 in WB, IHC and ICC. It exhibits reactivity toward Rat.

Quick Overview for KCNT1 antibody (AA 1168-1237) (ABIN1304962)

Target: KCNT1 (Potassium Channel, Subfamily T, Member 1 (KCNT1))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N3-26

Product Details anti-KCNT1 Antibody

Binding Specificity: AA 1168-1237

Specificity: No off-targets reported

Cross-Reactivity: Human, Marine Mollusks (Liolophura), Mouse, Rat

Characteristics:

Description: Our Anti-Slo2.2/Slack K+ channel mouse monoclonal primary antibody is produced in-house from hybridoma clone N3/26. It is KO validated, detects human, marine mollusk, mouse, and rat Slo2.2/Slack K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Manufacturer Comment: We produce our Slo2.2/Slack K+ channel mouse monoclonal primary antibody from hybridoma clone N3/26. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Purity: > 90% specific antibody

Immunogen: Fusion protein amino acids 1168-1237 of rat Slo2.2 (accession number NP_068625) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes:

Dilution Range: IHC: 1:400

Dilution Range: ICC: 1:250

Dilution Range: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 24 months

Target Details for KCNT1

Target: KCNT1 (Potassium Channel, Subfamily T, Member 1 (KCNT1))

Alternative Name: Slo2.2

Background:

Synonyms: Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit)

Target Description: Potassium channel subfamily T member 1 or -KCNT1/Slo2.2/Slack K+ channel is encoded by the gene KCNT1. Slo2.2 is a member of the the voltage-gated ion channel (vic) superfamily, and the KCNT protein family, which is made of KCNT1 and KCNT2. Slo2.2 functions as an outwardly rectifying potassium channel subunit to contribute to ion conductance and signaling pathways. Slo2.2 can be activated by high intracellular sodium or chloride levels. Slo2.2 is expressed at the membrane in many areas of the brain, brainstem, spinal cord, spleen and liver. Mutations in this gene cause the early-onset epileptic disorders

Gene Name Alternatives: Kcnt1 Slack

Molecular Weight: 140 kDa

NCBI Accession: NP_068625