IL-10 antibody

Catalog No. ABIN1383949

This Mouse Monoclonal antibody specifically detects IL-10 in IHC, ELISA and Func. It exhibits reactivity toward Human and Mouse and has been mentioned in 11+ publications.

Quick Overview for IL-10 antibody (ABIN1383949)

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-10 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Functional Studies (Func)

Clone: B-S10

Product Details anti-IL-10 Antibody

Specificity: Recognises both natural and recombinant human IL-10

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Recombinant human IL-10,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotype: IgG1 kappa

Biological Activity Comment: Blocks IL-10 induced inhibition of IL-6 synthesis on LPS activated monocytes

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL-10 antibody (ABIN1383949)

Naji, Le Rond, Durrbach, Krawice-Radanne, Creput, Daouya, Caumartin, LeMaoult, Carosella, Rouas-Freiss: "CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance." in: Blood, Vol. 110, Issue 12, pp. 3936-48, (2007) (PubMed).

Ravirajan, Wang, Matis, Papadaki, Griffiths, Latchman, Isenberg: "Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody." in: Rheumatology (Oxford, England), Vol. 43, Issue 4, pp. 442-7, (2004) (PubMed).

Fontana, Moratto, Mangal, De Francesco, Vermi, Ferrari, Facchetti, Kutukculer, Fiorini, Duse, Das, Notarangelo, Plebani, Badolato: "Functional defects of dendritic cells in patients with CD40 deficiency." in: Blood, Vol. 102, Issue 12, pp. 4099-106, (2004) (PubMed).

Brok, van Meurs, Blezer, Schantz, Peritt, Treacy, Laman, Bauer, t Hart: "Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6554-63, (2002) (PubMed).

Debili, Robin, Schiavon, Letestu, Pflumio, Mitjavila-Garcia, Coulombel, Vainchenker: "Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates." in: Blood, Vol. 97, Issue 7, pp. 2023-30, (2001) (PubMed).

Schrijver, van Meurs, Melief, Wim Ang, Buljevac, Ravid, Hazenberg, Laman: "Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis." in: Brain : a journal of neurology, Vol. 124, Issue Pt 8, pp. 1544-54, (2001) (PubMed).

Egeler, Favara, van Meurs, Laman, Claassen: "Differential In situ cytokine profiles of Langerhans-like cells and T cells in Langerhans cell histiocytosis: abundant expression of cytokines relevant to disease and treatment." in: Blood, Vol. 94, Issue 12, pp. 4195-201, (2000) (PubMed).

Villoslada, Hauser, Bartke, Unger, Heald, Rosenberg, Cheung, Mobley, Fisher, Genain: "Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system." in: The Journal of experimental medicine, Vol. 191, Issue 10, pp. 1799-806, (2000) (PubMed).

Balashov, Comabella, Ohashi, Khoury, Weiner: "Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS." in: Neurology, Vol. 55, Issue 2, pp. 192-8, (2000) (PubMed).

Lelievre, Sarrouilhe, Morel, PreudHomme, Wijdenes, Lecron: "Preincubation of human resting T cell clones with interleukin 10 strongly enhances their ability to produce cytokines after stimulation." in: Cytokine, Vol. 10, Issue 11, pp. 831-40, (1999) (PubMed).

Schandené, Alonso-Vega, Willems, Gérard, Delvaux, Velu, Devos, de Boer, Goldman: "B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 9, pp. 4368-74, (1994) (PubMed).

Target Details for IL-10

Target: IL-10 (IL10) (Interleukin 10 (IL10))

Alternative Name: IL-10

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints