RPGRIP1L antibody (AA 41-140)

Catalog No. ABIN1385221

This Rabbit Polyclonal antibody specifically detects RPGRIP1L in WB, ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for RPGRIP1L antibody (AA 41-140) (ABIN1385221)

Target: RPGRIP1L (RPGRIP1-Like (RPGRIP1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPGRIP1L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RPGRIP1L Antibody

Binding Specificity: AA 41-140

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RPGRIP1L

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RPGRIP1L

Target: RPGRIP1L (RPGRIP1-Like (RPGRIP1L))

Alternative Name: RPGRIP1L

Background:

Synonyms: CORS 3, CORS3, Fantom, FTM, JBTS 1, JBTS 7, JBTS1, JBTS7, Joubert syndrome 1, Joubert syndrome 7, Meckel syndrome, type 1, RPGRIP1-like, Meckel syndrome, type 5, MKS 5, MKS5, NPHP 8, NPHP8, nephrocystin 8, Protein fantom, Retinitis pigmentosa GTPase regulator interacting protein 1 like, RPGR interacting protein 1 like protein, RPGRIP1 like protein, FTM_HUMAN.

Background: RPGRIP1L is a 1,315 amino acid protein that belongs to the RPGRIP1 family and is thought to function in programmed cell death, craniofacial development and formation of the left-right axis. Existing as two alternatively spliced isoforms that localize to the cytoplasm, cytoskeleton, centrosome and cilium basal body, RPGRIP1L interacts with nephrocystin-4 and is moderately expressed in brain, retina and kidney. Containing two C2 domains, RPGRIP1L is encoded by a gene that maps to human chromosome 16q12.2. Defects in the gene encoding RPGRIP1L are the cause of Joubert syndrome type 7 (JBTS7), COACH syndrome (COACHS) and Meckel syndrome type 5 (MKS5).

Pathways: DNA Replication, Regulation of G-Protein Coupled Receptor Protein Signaling, Synthesis of DNA