TPD52L1 antibody

Catalog No. ABIN1385481

The Rabbit Polyclonal anti-TPD52L1 antibody (ABIN1385481) specifically detects TPD52L1 in WB, IHC (p) and IF (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TPD52L1 antibody (ABIN1385481)

Target: TPD52L1 (Tumor Protein D52-Like 1 (TPD52L1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPD52L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TPD52L1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TPD52L1/D53

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TPD52L1

Target: TPD52L1 (Tumor Protein D52-Like 1 (TPD52L1))

Alternative Name: D53

Background:

Synonyms: D53, D54, hD53, hD54, Tpd52l1, TPD52L2 TPD53_HUMAN, Tumor protein D52 like 1, Tumor protein D52 like 2, Tumor protein D52-like 1, Tumor protein D53, Tumor protein D54.

Background: The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.

Gene ID: 7164

Pathways: Positive Regulation of Endopeptidase Activity