NR2E3 antibody (AA 1-100)

Catalog No. ABIN1385816

The Rabbit Polyclonal anti-NR2E3 antibody is suitable to detect NR2E3 in samples from Human. It has been validated for WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) and ICC.

Quick Overview for NR2E3 antibody (AA 1-100) (ABIN1385816)

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2E3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-NR2E3 Antibody

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NR2E3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NR2E3

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Alternative Name: NR2E3

Background:

Synonyms: ESCS, ESCS, NR2 E3, Nr2e3, NR2E3_HUMAN, Nuclear receptor subfamily 2 group E member 3, Photoreceptor specic nuclear receptor, Photoreceptor-specic nuclear receptor antibody PNR, Rd 7, rd7, Retina specic nuclear receptor, Retina-specic nuclear receptor, Retinal degeneration 7, Retinal degeneration 7, RNR, RP37.

Background: Photoreceptor-specific nuclear receptor, also known as NR2E3 or PNR, belongs to a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E3 has a role in regulating the signaling pathway elemental to the photoreceptor cell function and in regulating pathways involved in embryonic development. NR2E3 is an eye specific nuclear protein found in the outer nuclear layer of the adult retina (where the nuclei of cone and rod photoreceptors are located). Defects in this gene encoding for the protein, which localizes to chromosome 15q22.32, cause enhanced S cone syndrome.

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway