GluR1, GluR2 antibody (AA 141-240)

Catalog No. ABIN1385842

Product Details anti-GluR1, GluR2 Antibody

Target: GluR1, GluR2 (GRIA1/2) (Glutamate Receptor, Ionotropic, AMPA 1/2 (GRIA1/2))

Binding Specificity: AA 141-240

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GluR1, GluR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunocytochemistry (ICC)

Specificity: Due to the similarity of this protein to GluR2, there is a chance that this antibody will react with this protein based on homology.

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GluR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-GluR1, GluR2 antibody (ABIN1385842)

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Zhang, Zhang, Li, Xu, Chu, Chen, Chen: "Antioxidant and anti-excitotoxicity effect of Gualou Guizhi decoction on cerebral ischemia/reperfusion injury in rats." in: Experimental and therapeutic medicine, Vol. 9, Issue 6, pp. 2121-2126, (2015) (PubMed).

Target Details for GluR1, GluR2

Target: GluR1, GluR2 (GRIA1/2) (Glutamate Receptor, Ionotropic, AMPA 1/2 (GRIA1/2))

Alternative Name: GluR1, GluR2 (GRIA1/2 Products)

Background:

Synonyms: GLUH1, GLUR1, GLURA, GluA1, HBGR1, Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GRIA1

Background: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene ID: 2890

UniProt: P42261