KCNQ2 antibody (AA 91-150)

Catalog No. ABIN1385873

Product Details anti-KCNQ2 Antibody

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Binding Specificity: AA 91-150

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ2 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNQ2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for KCNQ2

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Alternative Name: KCNQ2 (KCNQ2 Products)

Background:

Synonyms: BFNC, BFNS1, EBN 1, EBN, EBN1, EIEE7, ENB 1, ENB1, HNSPC, KCNA 11, KCNA11, KCNQ 2, Kcnq2, KCNQ2_HUMAN, KQT like 2, KQT-like 2, KV7.2, KVEBN 1, KVEBN1, KvLQT 2, KvLQT2, Neuroblastoma specic potassium channel alpha subunit KvLQT2, Neuroblastoma specic potassium channel protein, Neuroblastoma specic potassium channel subunit alpha, Neuroblastoma specic potassium channel subunit alpha KvLQT2, Neuroblastoma-specic potassium channel subunit alpha KvLQT2, Potassium voltage gated channel KQT like protein 2, Potassium voltage gated channel KQT like subfamily member 2, Potassium voltage gated channel subfamily KQT member 2, Potassium voltage-gated channel subfamily KQT member 2, Voltage gated potassium channel subunit Kv7.2, Voltage-gated potassium channel subunit Kv7.2.

Background: Epilepsy affects about 0.5 % of the world?s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap.