HEXIM1 antibody

Catalog No. ABIN1386067

This Rabbit Polyclonal antibody specifically detects HEXIM1 in WB, IHC (p) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HEXIM1 antibody (ABIN1386067)

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEXIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HEXIM1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HEXIM1/EDG1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for HEXIM1

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Alternative Name: HEXIM1

Background:

Synonyms: Cardiac lineage protein 1, CLP 1, CLP1, EDG 1, EDG1, Estrogen down-regulated gene 1 protein, Hexamethylene bis acetamide inducible 1, Hexamethylene bis acetamide inducible protein, Hexamethylene bis acetamide inducible transcript 1, Hexamethylene bis-acetamide-inducible protein 1, HEXI1_HUMAN, HEXIM 1, Hexim1, HEXIM1 protein, HIS 1, HIS1, HMBA inducible, MAQ 1, MAQ1, Menage a quatre 1, Menage a quatre protein 1, Protein HEXIM1.

Background: Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.

Gene ID: 10614