TWF2 antibody (AA 51-150)

Catalog No. ABIN1386208

This Rabbit Polyclonal antibody specifically detects TWF2 in WB, ELISA, IHC (p), ICC, IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for TWF2 antibody (AA 51-150) (ABIN1386208)

Target: TWF2 (Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila) (TWF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TWF2 Antibody

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TWF2/PTK9L

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TWF2

Target: TWF2 (Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila) (TWF2))

Alternative Name: TWF2/PTK9L

Background:

Synonyms: A6 related protein, A6r, A6RP, hA6RP, MSTP011, Protein tyrosine kinase 9 like, PTK 9L, PTK9L,PTK9L, PTK9L protein tyrosine kinase 9 like, TWF 2, Twinfilin 1 like protein, Twinfilin 2, Twinfilin actin binding protein homolog 2, Twinfilin like protein, Twinfilin2, TWF2_HUMAN.

Background: Twinfilin-2 is a 349 amino acid protein that localizes to the perinuclear region of the cytoplasm, as well as to the cytoskeleton, and contains two ADF-H domains. Expressed ubiquitously, Twinfilin-2 functions as an Actin-binding protein that is able to both bind and sequester G-Actin and cap the barbed ends of Actin filaments, thereby inhibiting Actin polymerization and playing a role in Actin-related motile and morphological processes. Twinfilin-2 is subject to post-translational phosphorylation by PKC zeta. The gene encoding Twinfilin-2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Pathways: Regulation of Actin Filament Polymerization, Regulation of Cell Size, Maintenance of Protein Location, Toll-Like Receptors Cascades