Contactin 3/4/5/6 (AA 181-280) antibody

Catalog No. ABIN1386333

The Rabbit Polyclonal anti-Contactin 3/4/5/6 antibody (ABIN1386333) specifically detects Contactin 3/4/5/6 in WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) and ICC. The antibody is reactive with Human samples.

Quick Overview for Contactin 3/4/5/6 (AA 181-280) antibody (ABIN1386333)

Target: Contactin 3/4/5/6

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details

Binding Specificity: AA 181-280

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Contactin 4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Contactin 3/4/5/6

Background:

Synonyms: AXCAM, axonal-associated cell adhesion molecule, BIG 2, BIG2, Brain-derived immunoglobulin superfamily protein 2, CNTN4, CNTN4A, CNTN4_HUMAN, CNTN6, CNTN6_HUMAN, Contactin 4, Contactin4, Contactin-4, Contactin-6, Contactin6, Contactin 6, hNB-3, NB3, neural cell adhesion protein BIG-2, Neural recognition molecule NB-3, Contactin-3, Brain-derived immunoglobulin superfamily protein 1, BIG-1, Plasmacytoma-associated neuronal glycoprotein, CNTN3, KIAA1496, PANG, Contactin-5, Neural recognition molecule NB-2, hNB-2, CNTN5

Background: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.