SCN7A antibody (AA 1561-1582)

Catalog No. ABIN1386696

Product Details anti-SCN7A Antibody

Target: SCN7A (Sodium Channel, Voltage-Gated, Type VII, alpha Subunit (SCN7A))

Binding Specificity: AA 1561-1582

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN7A antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SCN7A

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SCN7A

Target: SCN7A (Sodium Channel, Voltage-Gated, Type VII, alpha Subunit (SCN7A))

Alternative Name: SCN7A (SCN7A Products)

Background:

Synonyms: Putative voltage gated sodium channel subunit alpha Nax, SCN 6A, SCN 7A, SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha, Sodium channel protein type 7 subunit alpha, Sodium channel protein type VII subunit alpha, Sodium channel voltage gated type VI alpha polypeptide, Sodium channel voltage gated type VII alpha, Sodium channel voltage gated type VII alpha polypeptide, Voltage dependent sodium channel alpha subunit, SCN7A_HUMAN.

Background: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Beta subunit, a noncovalently associated Beta 1 subunit and a disulfide-linked Beta 2 subunit. Na+ CP type VII Alpha (Sodium channel protein type 7 subunit alpha), also known as SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha and putative voltage-gated sodium channel subunit alpha Nax, is a 1682 amino acid multi-pass membrane protein that belongs to the sodium channel family. Primarily expressed in uterus and heart, Na+ CP type VII Alpha may function in the regulation of salt intake behavior and central sensing of body-fluid sodium levels.

Gene ID: 6332

UniProt: Q01118