PANK1 antibody

Catalog No. ABIN1386809

The Rabbit Polyclonal anti-PANK1 antibody has been validated for WB, IF (p) and IHC (p). It is suitable to detect PANK1 in samples from Human, Mouse and Rat.

Quick Overview for PANK1 antibody (ABIN1386809)

Target: PANK1 (Pantothenate Kinase 1 (PANK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PANK1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PANK1

Isotype: IgG

Application Details

Application Notes: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PANK1

Target: PANK1 (Pantothenate Kinase 1 (PANK1))

Alternative Name: PANK1

Background:

Synonyms: coaA, hPanK, hPanK1, PANK, PANK1, PANK1_HUMAN, PANK1a, PANK1b, PanK1beta, Pantothenate kinase 1, Pantothenate kinase, Pantothenic acid kinase 1.

Background: The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA). Pantothenate kinase 1 (PANK1) is a 598 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK1 is strongly inhibited by acetyl-CoA and manyl-CoA, as well as by high concentration of non-esterified CoA (CoASH). Four known isoforms of PANK1 exist as a result of alternative splicing events. Of these isoforms, PANK1a and PANK1b have been identified as the catalytically active isoforms. Isoform PANK1a is most highly expressed in brain, heart, kidney, liver, skeletal muscle and kidney. Isoform PANK1b is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.

Gene ID: 53354

UniProt: Q8TE04

Pathways: Ribonucleoside Biosynthetic Process