FBXL21 antibody (AA 121-220)

Catalog No. ABIN1386850

This Rabbit Polyclonal antibody specifically detects FBXL21 in ELISA, WB, IF (cc), IF (p), IHC (fro) and IHC (p). It exhibits reactivity toward Mouse.

Quick Overview for FBXL21 antibody (AA 121-220) (ABIN1386850)

Target: FBXL21 (F-Box and Leucine-Rich Repeat Protein 21 (FBXL21))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL21 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FBXL21 Antibody

Binding Specificity: AA 121-220

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBXL21/FBL3B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FBXL21

Target: FBXL21 (F-Box and Leucine-Rich Repeat Protein 21 (FBXL21))

Alternative Name: FBXL21

Background:

Synonyms: F box and leucine rich repeat protein 21, F box and leucine rich repeat protein 3 pseudogene, F box and leucine rich repeat protein 3B, F box protein Fbl3b, F box/LRR repeat protein 21, F box/LRR repeat protein 3B, Fbl 21, FBXL 21, FBXL-21, FBL 3, FBL 3B, Fbl21, FBL3, FBL-3B, FBL 3B, FBL3B, FBXL 21, FBXL 3B, FBXL 3P, FBXL3B, FBXL3P, MGC120237, FXL21_HUMAN.

Background: FBL3B is a 434 amino acid protein encoded by the human gene FBXL21. FBL3B contains one 40 amino acid F-box region, making it a member of the F-box family. FBL3B also contains three LRR (leucine-rich) repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. FBL3B is a substrate-recognition component of the SCF complex that interacts with Skp1 p19 and CUL-1. FBL3B is also associated with expression and regulation of circadian and cryptochrome proteins.

Gene ID: 26223

Pathways: Photoperiodism