DSPP antibody

Catalog No. ABIN1386864

This anti-DSPP antibody is a Rabbit Polyclonal antibody detecting DSPP in IF (p) and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for DSPP antibody (ABIN1386864)

Target: DSPP (Dentin Sialophosphoprotein (DSPP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DSPP antibody is un-conjugated

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DSPP Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DSPP/Dentin phosphophoryn

Isotype: IgG

Application Details

Application Notes: IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DSPP

Target: DSPP (Dentin Sialophosphoprotein (DSPP))

Alternative Name: DSPP

Background:

Synonyms: Dentin phosphophoryn, Dentin phosphoprotein, dentin phosphoryn, Dentin sialophosphoprotein, Dentin sialophosphoprotein precursor, Dentin sialoprotein, dentinogenesis imperfecta 1, DFNA39, DGI1, DMP3, DPP, DSP, Dspp, DSPP_HUMAN, DTDP2.

Background: DSPP may be an important factor in dentinogenesis. DSPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.The dentin sialophosphoprotein (DSPP) gene encodes two major noncollagenous dentin matrix proteins: dentin sialoprotein, known as DSP, and dentin phosphoprotein, known as phosphophoryn or DPP. The DSPP gene maps to human chromosome 4 and yields a 4.6 kb transcript containing 5 exons, with exons 1-4 encoding for DSP and exon 5 encoding for both the C-terminus of DSP and the full length DPP. DPP and DSP are acidic proteins that represent about 50 % of the noncollagenous proteins in the dentin extracellular matrix of teeth. The DSPP gene is a likely candidate gene for the genetic diseases associated with abnormal dentin formation such as dentinogenesis imperfecta type II and dentin dysplasia type II. DPP may bind large amounts of calcium and may facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.

Gene ID: 1834