SERPINA10 antibody

Catalog No. ABIN1386982

This Rabbit Polyclonal antibody specifically detects SERPINA10 in WB, IF (p) and IHC (p). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for SERPINA10 antibody (ABIN1386982)

Target: SERPINA10 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 (SERPINA10))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINA10 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SERPINA10 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZPI/SERPINA10

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SERPINA10

Target: SERPINA10 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 (SERPINA10))

Alternative Name: SERPINA10

Background:

Synonyms: Protein Z dependent protease inhibitor, Protein Z dependent protease inhibitor precursor, Protein Z-dependent protease inhibitor, PZ dependent protease inhibitor, PZ-dependent protease inhibitor, PZI, serine or cysteine proteinase inhibitor clade A alpha 1 antiproteinase antitrypsin member 10 , Serpin A10, Serpin peptidase inhibitor clade A alpha 1 antiproteinase antitrypsin member 10, SERPINA 10, SERPINA10, ZPI, ZPI_HUMAN.

Background: ZPI, also known as SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10) or PZI, is a 444 amino acid secreted protein that functions as a Protein Z-dependent protease inhibitor. Expressed by the liver, ZPI is secreted into the plasma where, in the presence of calcium, Protein Z and phospholipids, it inhibits the activated pro-coagulation factors X and XI (Factor X and Factor XI). This inhibition helps properly regulate intravenous blood clotting. ZPI, a member of the serpin protein family, contains five potential N-linked glycosylation sites and a tyrosine at position 387 which, when disrupted, renders ZPI inactive. Defects in the gene encoding ZPI may increase susceptibility to venous thrombosis, the formation of blood clots within a vein.

Gene ID: 51156