Kininogen-1 Light Chain antibody

Catalog No. ABIN1387091

The Rabbit Polyclonal anti-Kininogen-1 Light Chain antibody is suitable to detect Kininogen-1 Light Chain in samples from Human, Mouse and Rat. It has been validated for WB, IF (p) and IHC (p).

Quick Overview for Kininogen-1 Light Chain antibody (ABIN1387091)

Target: Kininogen-1 Light Chain

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HMW Kininogen-1 light chain

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Kininogen-1 Light Chain

Background:

Synonyms: Alpha 2 thiol proteinase inhibitor, HMW Kininogen light Chain, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, Kininogen 1, KNG1, KNG1_HUMAN, Low molecular weight growth-promoting factor, Williams-Fitzgerald-Flaujeac factor.

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

Gene ID: 3827