B4GALT7 antibody

Catalog No. ABIN1387134

This anti-B4GALT7 antibody is a Rabbit Polyclonal antibody detecting B4GALT7 in WB, IF (p) and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for B4GALT7 antibody (ABIN1387134)

Target: B4GALT7 (Xylosylprotein beta 1,4-Galactosyltransferase, Polypeptide 7 (Galactosyltransferase I) (B4GALT7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This B4GALT7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-B4GALT7 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human B4GALT7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for B4GALT7

Target: B4GALT7 (Xylosylprotein beta 1,4-Galactosyltransferase, Polypeptide 7 (Galactosyltransferase I) (B4GALT7))

Alternative Name: B4GALT7

Background:

Synonyms: B4GAL T7, Beta 1,4 galactosyltransferase 7, Beta 1,4 GalTase 7, Beta4Gal T7, UDP Gal:beta GlcNAc beta 1,4 galactosyltransferase 7, XGALT 1, XGALT1, XGPT1, Xylosylprotein beta 1,4 galactosyltransferase, polypeptide 7, B4GT7_HUMAN.

Background: Beta-1,4-galactosyltransferases (beta-1,4-Gal-T) are type II membrane-bound glycoproteins that are substrate-specific and function to transfer galactose in a beta-1,4 linkage to an acceptor sugar. There are seven members of the beta-1,4-Gal-T family, all of which are directed to the golgi apparatus through a hydrophobic sequence at the N-terminus. Beta-1,4-Gal-T7, also known as B4GALT7 or XGALT1, is a 327 amino acid single-pass type II membrane protein that is expressed at high levels in heart, pancreas and liver. Beta-1,4-Gal-T7 uses manganese to catalyze the UDP-dependent biosynthesis of glycosphingolipids. The gene encoding beta-1,4-Gal-T7 is mutated in Ehlers-Danlos syndrome progeroid type (EDSP), a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits. Beta-1,4-galactosyltransferases (Beta-1,4-Gal-T) are type II membrane-bound glycoproteins that are substrate-specific and function to transfer galactose in a beta-1,4 linkage to an acceptor sugar.

Gene ID: 11285

Pathways: Glycosaminoglycan Metabolic Process