TNIP1 antibody

Catalog No. ABIN1387564

This Rabbit Polyclonal antibody specifically detects TNIP1 in WB, IHC (p) and IF (p). It exhibits reactivity toward Human, Mouse and Ratand has been mentioned in 1 publication.

Quick Overview for TNIP1 antibody (ABIN1387564)

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TNIP1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNIP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TNIP1 antibody (ABIN1387564)

Zhou, Lu, Wang, Li, Luo: "A20-Binding Inhibitor of NF-κB 1 Ameliorates Neuroinflammation and Mediates Antineuroinflammatory Effect of Electroacupuncture in Cerebral Ischemia/Reperfusion Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2020, pp. 6980398, (2020) (PubMed).

Target Details for TNIP1

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Alternative Name: TNIP1

Background:

Synonyms: ABIN 1, ABIN-1, abin1, HIV-1 Nef interacting protein Nip40-1, TNFAIP3 interacting protein 1, HIV-1 Nef interacting protein, HIV-1 Nef-interacting protein, hVAN, KIAA0113, NAF 1, NAF-1, NAF1, Nef-associated factor 1, Nef-associated factor 1 SNP, Nip 40-1, Nip40-1, TNFAIP3 interacting protein 1, TNFAIP3-interacting protein 1, TNIP 1, TNIP-1, Tnip1, TNIP1_HUMAN, VAN, Virion associated nuclear shuttling protein, Virion-associated nuclear shuttling protein.

Background: Abin-1 is a 636 amino acid protein that localizes to both the nucleus and the cytoplasm and is shuttled between the two intercellular regions in a CRM1-dependent manner. Expressed ubiquitously with highest expression in spleen and skeletal muscle, Abin-1 interacts with A20 and, via this interaction, interferes with TRAF2-mediated transactivation signals and effectively inhibits TNF-induced NF_B expression. Additionally, Abin-1 can be incorporated into HIV-1 virions and, if overexpressed, can inhibit viral replication. Abin-1 may also play an important role in the regulation of nuclear import and export activities. Multiple isoforms of Abin-1 exist due to alternative splicing events.

Pathways: Activation of Innate immune Response