SYT11 antibody (AA 51-100)

Catalog No. ABIN1387635

This anti-SYT11 antibody is a Rabbit Polyclonal antibody detecting SYT11 in ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p). Suitable for Human.

Quick Overview for SYT11 antibody (AA 51-100) (ABIN1387635)

Target: SYT11 (Synaptotagmin XI (SYT11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYT11 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SYT11 Antibody

Binding Specificity: AA 51-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Synaptotagmin XI

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SYT11

Target: SYT11 (Synaptotagmin XI (SYT11))

Alternative Name: Synaptotagmin 11

Background:

Synonyms: Synaptotagmin 11, Synaptotagmin 12, Synaptotagmin XI, Synaptotagmin-11, synaptotagmin XII, synaptotagmin-XII, Synaptotagmin11, Synaptotagmin12, Synaptotagmin-11, Synaptotagmin-12, SynaptotagminXI, SYT 11, SYT 12, SYT-11, SYT-12, Syt XI, Syt11, SYT11_HUMAN, SYT12, SytXI, DKFZp781D015, KIAA0080, MGC10881, MGC17226.

Background: Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson?s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson?s disease.

Gene ID: 23208