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GBX2 antibody (AA 251-348)

The Rabbit Polyclonal anti-GBX2 antibody has been validated for WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) and ICC. It is suitable to detect GBX2 in samples from Rat.
Catalog No. ABIN1387700

Quick Overview for GBX2 antibody (AA 251-348) (ABIN1387700)

Target

See all GBX2 Antibodies
GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reactivity

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  • 18
  • 4
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  • 3
  • 2
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  • 2
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  • 1
Rat

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This GBX2 antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
  • Binding Specificity

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    AA 251-348

    Cross-Reactivity

    Rat

    Predicted Reactivity

    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Gbx2

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

    Alternative Name

    Gbx2

    Background

    Synonyms: Gastrulation and brain-specic homeobox protein 2, Gastrulation brain homeo box 2 , Gastrulation brain homeo box 2, gbx2, GBX2_HUMAN, Homeobox protein GBX 2 , Homeobox protein GBX 2, Homeobox protein GBX-2, Homeobox protein STRA7, Mmoxa.

    Background: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes Gbx2 and Otx2. Gbx2 and Otx2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, Gbx2 negatively regulates Otx2 expression along the anterior-posterior axis, Gbx2(-) mutants demonstrate an expanded Otx2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. Gbx2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is over-expressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of Gbx2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that Gbx2 expression may be required for growth of malignant prostate cells.

    Pathways

    Dopaminergic Neurogenesis
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