DOCK3 antibody (AA 1001-1100)

Catalog No. ABIN1387818

This anti-DOCK3 antibody is a Rabbit Polyclonal antibody detecting DOCK3 in ELISA, WB, ICC, IF (cc), IF (p), IHC (fro) and IHC (p). Suitable for Human.

Quick Overview for DOCK3 antibody (AA 1001-1100) (ABIN1387818)

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DOCK3 Antibody

Binding Specificity: AA 1001-1100

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DOCK3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Alternative Name: DOCK3

Background:

Synonyms: Dedicator of cytokinesis protein 3, DOCK 3, MOCA, Modier of cell adhesion, Presenilin binding protein, DOCK3_HUMAN.

Background: MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.