MYRIP antibody (AA 101-200)

Catalog No. ABIN1387849

This Rabbit Polyclonal antibody specifically detects MYRIP in ELISA, WB, IHC (p), ICC, IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for MYRIP antibody (AA 101-200) (ABIN1387849)

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYRIP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MYRIP Antibody

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYRIP/SLAC2-C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MYRIP

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Alternative Name: MYRIP/SLAC2-C

Background:

Synonyms: exophilin 8, exophilin, Exophilin-8, Exophilin8, Myosin VIIA and Rab interacting protein, Myosin-VIIa- and Rab-interacting protein, MyRIP, MYRIP_HUMAN, rab effector MYRIP, SLAC 2C, SLAC2 C, SLAC2-C, SLAC2C, Slp homolog lacking C2 domains c, Slp homologue lacking C2 domains, Slp homologue lacking C2 domains c antibody Synaptotagmin like protein homologue lacking C2 domains c, synaptotagmin-like protein homologue lacking C2 domains-c.

Background: Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton.

Pathways: Positive Regulation of Peptide Hormone Secretion