alpha 2 Macroglobulin antibody

Catalog No. ABIN1387864

This Rabbit Polyclonal antibody specifically detects alpha 2 Macroglobulin in WB, IHC (p) and IF (p). It exhibits reactivity toward Human, Rat, Mouse, Chicken and Cow and has been mentioned in 3+ publications.

Quick Overview for alpha 2 Macroglobulin antibody (ABIN1387864)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human, Rat, Mouse, Chicken, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-alpha 2 Macroglobulin Antibody

Cross-Reactivity: Chicken, Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-alpha 2 Macroglobulin antibody (ABIN1387864)

Liu, Wang, Liu, Wang, Zheng, Tan, Xing, Cui, Li, Zhao, Wen: "Uncovering the embryonic development-related proteome and metabolome signatures in breast muscle and intramuscular fat of fast-and slow-growing chickens." in: BMC genomics, Vol. 18, Issue 1, pp. 816, (2017) (PubMed).

Shu, Bai, Wang, Xiao, Fan, Zhang, Zhao, Zhao, Xia, Zhang: "Differentially expressed serum proteins associated with calcium regulation and hypocalcemia in dairy cows." in: Asian-Australasian journal of animal sciences, Vol. 30, Issue 6, pp. 893-901, (2017) (PubMed).

Hu, Lin, Zhu, Li, Chen: "Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected]." in: Molecular medicine reports, Vol. 12, Issue 3, pp. 3998, (2015) (PubMed).

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: alpha 2 Macroglobulin

Background:

Synonyms: A2M, A2MG_HUMAN, Alpha 2 M, Alpha 2M, Alpha-2-M, Alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, DKFZp779B086, FWP007, S863 7.

Background: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].

Gene ID: 2

Pathways: Lipid Metabolism